Scintigraphy, nuclear medicine or a so called ‘bone scan’ provides a comprehensive view of the entire skeleton of the horse. After a thorough warm-up, the patient is injected with a radioactive substance bound to a specific carrier molecule targeting the tissue to be imaged. For a bone scan, the radioactive carrier complex (Tc99m-HDP) is bound to the mineral part of bone (hydroxyapatite). With a dedicated high resolution gamma camera, the entire skeleton can then be screened for so called hotspots or ‘IRU’ (increased radiopharmaceutical uptake) on the images indicate increased bone activity, which may result from various issues including osteoarthritic changes, inflammation, infection or other bone damage like bone edema, fractures, and cysts. Bone scans are often conducted in cases of performance issues, back, neck, and pelvis problems, unlocalized lameness, multiple leg issues, or suspected undetectable fractures (e.g., pelvis). Scintigraphy is performed with the horse standing.